A Study of YEATS4 Is an Amplifier in the Epigenetic-Metabolic Circuit that Is Wired to Fatty-acid Metabolism and Cancer Cell Stemness , Peng et al

In this study, we report that YEATS4 is an epigenetic reader of H3K14cr that impacts on cellular metabolomics, especially the metabolism of fatty acids. We showed that YEATS4 recognizes H3K14cr and activates the transcription of a panel of genes, including CD36, CPT1A, and ACOX1 that are critically involved in fatty acid uptake and metabolism. We showed that YEATS4 is upregulated in ALDH+ BCSCs and is associated with augmented fatty-acid metabolism, enhanced stemness, and accelerated tumor growth. The provided dataset comprises all original, uncropped images used in the study, such as western blots, colony formation assays, SDS-PAGE gels, brightfield microscopy, and tumor image from all mice, to support our hypothesis.