Olfr2 drives abdominal aortic aneurysm by promoting monocyte recrutiment

Olfactory receptor 2 is a G-protein coupled receptor expressed on vascular macrophages. Activation by its ligand octanal in conjuction with a toll like receptor 4 stimulus induces the NLRP3 inflammasome with subsequent IL-1alpha and IL-1beta release. In this study we aim to investigate the effects of genetic Olfr2 deficiency on the development of abdominal aortic aneurysm (AAA). Overall design: RNA seq profiling of sorted Ly6Chigh monocytes from the spleen of Olfr2 WT and KO mice at day 7 after aneurysm induction