Removal of the Flap Intermediate from the C-strand

Two endonucleases, Dna2 and flap endonuclease 1 (FEN-1), are responsible for resolving the nascent flap structure (Tsurimoto and Stillman 1991). The Dna2 endonuclease/helicase in yeast is a monomer of approximately 172 kDa. Human FEN-1 is a single polypeptide of approximately 42 kDa. Replication Protein A regulates the switching of endonucleases during the removal of the displaced flap (Tsurimoto et al.1991).

两种内切酶，即 Dna2 和 flap 内切酶 1（FEN-1），负责解决新生突环结构（Tsurimoto 和 Stillman，1991年）。酵母中的 Dna2 内切酶/解旋酶是一种由约 172 kDa 组成的单体。人类 FEN-1 是一种由约 42 kDa 组成的单一多肽。复制蛋白 A 调节内切酶在去除移位突环过程中的切换（Tsurimoto 等人，1991年）。