SFPQ is a FTO binding protein that assists specific m6A demethylation

We identified the major RNA binding protein-SFPQ as a direct interaction partner of FTO. Our study showed that FTO and SFPQ were located in close proximity throughout the transcriptome and overexpression of SFPQ led to the demethylation of adjacent N6-methyladenosine on RNA Examination for alternation of RNA methylation states in overexpression SFPQ and overexpression vector cells.