Raw data for the association of genetic variants of ErbB4 gene and gestational diabetes mellitus
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Gestational diabetes (GDM) is one of the common complications of female pregnancy, which seriously affects the health of patients and their offspring. So far, the etiology has not yet been fully clarified. To clarify the relationship of Erb-b2 receptor tyrosine kinase 4 (ErbB4) genetic variants and GDM risk in a Chinese population, ErbB4 variants (rs1595064, rs1595065, rs1595066 and rs6719645) were selected and genotyped in 554 GDM cases and 641 healthy controls. The associations between variants and GDM risk were evaluated with the odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). The false-positive reporting probability (FPRP), multi-factor dimension reduction (MDR) and bioinformatics analysis were adopted to confirm the significant associations. A nomogram model was constructed to predict the risk of GDM. Association analysis demonstrated that the rs1595066 genotype performed a protective effect on GDM risk among whole subjects. Meanwhile, stratified analysis ..., , , 1\. Sample ID: Identification number of test sample
2\. Group: 1=GDM; 0=Control group
3\. Age: Age in years of participants
4\. Pre\-BMI: Prepregnancy body mass index
5\. Variants and genotypes assignment
* rs1595064 G > C: 1=GG genotype; 2=GC genotype;3=CC genotype
* rs1595065 A > G: 1=AA genotype; 2=AG genotype;3=GG genotype
* rs1595066 C > T: 1=CC genotype; 2=CT genotype;3=TT genotype
* rs6719645 C > T: 1=CC genotype; 2=CT genotype;3=TT genotype
* rs1595066 Dominant model(CT/TT vs. CC): 1=CC genotype;4=CT/TT genotypes
* rs1595066 Recessive model(TT vs.CC/CT): 5=CC/CT genotype;3=TT genotype;
6\. Variables for stratification analysis
* Age\_M (Mean age:30.09 years, 1=\"â¤30.09\"ï¼2= âï¼30.09â);
* Pre-BMI\_M (Mean pre-BMI:22.23 kg/m2,1=\"â¤22.23\"ï¼2= âï¼22.23â );
* SBP\_M (Mean SBP:110.08 mmHg,1=\"â¤110.08\"ï¼2= âï¼110.08â );
* DBP\_M (Mean DBP:69.53 mmHg,1=\"â¤69.53\"ï¼2= âï¼69.53â );
* FPG\_M (Mean FPG:4.79 mmol/L,1=\"â¤4.79\"ï¼2= âï¼4.79â );
* 1hPG\_M (Mean OGTT 1h:8.26 mmol/...
创建时间:
2025-07-30



