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KDM6 histone demethylase inhibitor GSK-J4 induces metal and stress responses in multiple myeloma cells

NIAID Data Ecosystem2026-03-14 收录

多发性骨髓瘤细胞应激反应

组蛋白去甲基化酶抑制剂

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE213294 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2022-09-16

组蛋白去甲基化酶抑制剂

化学结构

Additional file 3: Figure S2. Chemical structure of the KDM inhibitors used in the study.

DataCite Commons2024-12-18 更新110

LSD1-CoREST in complex with T108, long soaking

表观遗传靶点结构

组蛋白去甲基化酶抑制剂

LSD1-CoREST in complex with T108, long soaking Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4

Protein Data Bank Japan2025-08-20 更新40

Crystal structure of human JMJD2A in complex with compound KDOAM20A

蛋白质晶体学

组蛋白去甲基化酶抑制剂

Crystal structure of human JMJD2A in complex with compound KDOAM20A Descriptor: 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, LYSINE-SPECIFIC

Protein Data Bank Japan2024-11-13 更新30

Crystal structure of human JMJD2A in complex with compound 30

组蛋白去甲基化酶抑制剂

生物与药物结构设计

Crystal structure of human JMJD2A in complex with compound 30 Descriptor: 1,2-ETHANEDIOL, 2-(5-azanyl-2-oxidanyl-phenyl)pyridine-4-carboxylic acid, CHLORIDE ION, ... Authors: Velupillai, S, Krojer, T,

Protein Data Bank Japan2024-01-10 更新60

Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A

共价药物设计

组蛋白去甲基化酶抑制剂

The active sites of hundreds of human α-ketoglutarate (αKG) and Fe(II)-dependent dioxygenases are exceedingly well preserved, which challenges the design of selective inhibitors. We identified a nonc

Figshare2018-11-15 更新40

KDM6 histone demethylase inhibitor GSK-J4 induces metal and stress responses in multiple myeloma cells

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