Two new prenylated indole diketopiperazine alkaloids (PIDAs) penicamides A and B (1 and 2) and three new polyketides penicinones A−C (6−8), along with four known compounds deoxybrevianamide E (3), bre
Poly (ADP-ribose) polymerase 1 (PARP-1) is a critical enzyme involved in DNA damage repair and recombination, and shows great potential for drug development in the treatment of cancers with defective
Compounds 13 and 14 were evaluated against 11 PARP isoforms to reveal that both 13 and 14 were more potent and isoform selective toward inhibiting tankyrases (TNKSs) than the “standard” inhibitor 1 (X
