RNA-seq analysis of B-cell precursor acute lymphoblastic leukemia cell lines

RNA sequencing (RNA-seq) revealed a strong correlation between fusion gene types and gene expression profiles in clinical samples of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). To validate the use of BCP-ALL cell lines as a model system, we expanded the series of BCP-ALL cell lines and conducted RNA-seq analysis. Additionally, the RNA-seq data were comprehensively integrated into an existing database that includes somatic mutations and single nucleotide polymorphisms. The overarching goal of this project is to establish the largest BCP-ALL cell line platform for preclinical research.