Cryptococcus neoformans Transcriptome or Gene expression (NHGRI)

Cryptococcus neoformans is an opportunistic fungal pathogen of enormous clinical importance. A recent study from the Centers for Disease Control estimates that approximately one million new infections occur each year (53). In Africa, cryptococcosis is the third most common cause of death in patients with HIV/AIDS, and mortality from cryptococcal meningitis exceeds the death rate from tuberculosis (53). C. neoformans is also a model organism for studying the virulence of pathogenic eukaryotes (24).Recent phylogenetic studies highlighted the diversity and complex evolutionary relationships among genetic groups within the Cryptococcus species complex.