Gene expression study in SF3B1-mutated, NOTCH1-mutated and WT CLL cells

Mutations of SF3B1 in CLL induce alternative splicing in multiple transcripts, including DVL2. DVL2 in turn can act as a negative regulator of NOTCH1 signaling. Gene Expression Profile (GEP) was used to investigate the activation of the NOTCH1 pathway in presence of alternatively spliced DVL2. Constitutive gene expression in CLL cells bearing either SF3B1 mutations, NOTCH1 mutation or none of them (WT). Bioinformatic analyses were performed by GenespringGX