Structural Characterization of Consensus TetratricoPeptide Repeat (CTPR) Protein Nanoparticles via SAXS
收藏ESRF Portal2028-01-01 更新2026-04-23 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-ES-2011811620
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资源简介：
Ultra-small protein single-chain nanoparticles (SCNPs) offer promising potential for biomedical applications. Building on advances in synthetic polymer chain collapse through intramolecular cross-linking, this proposal aims to apply these principles to proteins using bioengineered Consensus TetratricoPeptide Repeat (CTPR) proteins as model systems. CTPR5-WT and CTPR5-K4, which differ in Lysine content, are identified as target proteins for structural analysis using SAXS. By systematically altering the functional sites along the polypeptide chain, this research seeks to reveal key design principles for developing advanced protein-based nanoparticles.
提供机构：
CIC biomaGUNE, Biomolecular Nanotechnology, Paseo de Miramón 194 Parque Científico y Tecnológico de Gipuzkoa, 20014, San sebastian, ES; CSIC - UPV/EHU, Centro de Fisica de Materiales, Paseo Manuel de Lardizabal 5, 20018 San Sebastian, Spain
创建时间：
2028-01-01
