Metadata on <i>csnk2a1</i> Mutant-Induced Morphological Phenotypes in Zebrafish

Okur-Chung Neurodevelopmental Syndrome (OCNDS) is a rare autosomal dominant disorder caused by heterozygous pathogenic variants of the CSNK2A1 gene. CSNK2A1 encodes the α-subunit of the CK2 (Casein Kinase 2) and is involved in diverse biological processes. In this study, we collected data by employing a CK2 inhibitor and overexpression of mutant and wild-type csnk2a1 mRNA in a zebrafish model to investigate the functional consequences of selected CSNK2A1 variants implicated in Okur-Chung Neurodevelopmental Syndrome (OCNDS). The dataset provides comprehensive dose-response data for a CK2 inhibitor, demonstrating how varying doses influence zebrafish morphology and phenotypic outcomes. In addition, the dataset includes analyses of specific morphological and phenotypic changes resulting from the expression of both wild-type and mutant csnk2a1 mRNA in zebrafish. It also covers rescue experiments aimed at mitigating these mutant phenotypes, highlighting the utility of zebrafish as an adaptable model system for examining the functional impact of CSNK2A1 mutations.