Mouse and human static glucose stimulated insulin secretion assay.

Figshare2018-11-12 更新2026-04-29 收录

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Mouse and human static glucose stimulated insulin secretion assay.

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2018-11-12

Reduced insulin secretion in WFS1-deficient mice may be related to downregulation of Trpm5

胰岛素功能

转录组学分析

Wolfram syndrome, an autosomal recessive disorder characterized by juvenile-onset diabetes mellitus and optic atrophy, is caused by mutations in the WFS1 gene. WFS1 encodes an endoplasmic reticulum re

NIAID Data Ecosystem60

Viral shRNA Knockdown of INS Promotor Activity in EndoC-βH1 Cells . Viral shRNA Knockdown of INS Promotor Activity in EndoC-βH1 Cells

基因表达调控

胰岛素功能

To inhibit INS expression, we used shRNA to target the INS promoter. We find that knocking down INS expression with such an shRNA targeting the INS promoter significantly affects expression of 259 gen

NIAID Data Ecosystem30

Liver and plasma chemistries of ADKD WT mice at 10 days p.t.

肝脏代谢研究

胰岛素功能

Mice were chow-fed, 10-week-old B6 (WT) males, intravenously injected with ADKD vectors expressing RNAi for lacZ or Ildr2. Measurements were taken at 10 days p.t. (following either a 24-hr fast “Faste

Figshare2015-12-02 更新20

Transcriptome analyses of human pancreatic islets and pseudoislets

细胞转录组学

胰岛素功能

We have observed an improvement of glucose-stimulated insulin secretion upon the formation of pseudoislets. Transcriptome analyses of islets and pseudoislets from the same human donor were performed t

NIAID Data Ecosystem60

The Type 2 Diabetes Associated Minor Allele of rs2237895 KCNQ1 Associates with Reduced Insulin Release Following an Oral Glucose Load

糖尿病遗传学

胰岛素功能

BackgroundPolymorphisms in the potassium channel, voltage-gated, KQT-like subfamily, member 1 (KCNQ1) have recently been reported to associate with type 2 diabetes. The primary aim of the present stud

NIAID Data Ecosystem30

Mouse and human static glucose stimulated insulin secretion assay.

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