A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data

Context : In the study of the efficacy of antimicrobials, there is a need for in vitro models that enable reproduction of the clinical pharmacokinetics of said antimicrobials. Such a possibility is provided with what is known as the hollow-fiber infection model. The limitation of current hollow-fiber setups is that they do not enable simulation of pharmacokinetic profiles exhibiting an absorption phase without making the experimental setup unwieldy. Objective : In the attached publication we endeavoured to develop an experimental setup enabling in vitro simulation of pharmacokinetic profiles exhibiting an absorption phase with minimal modification of the traditional setup. We showed the correctness of our setup by simulating human pharmacokinetics of linezolid. In this dataset you can find linezolid concentration data used to validate our novel hollow-fiber setup to reproduce first order absorption. Reuse : The data could be reused to validate your local implementation of our experimental setup.