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Cellular Localization of the Herpes Simplex Virus ICP0 Protein Dictates Its Ability to Block IRF3-Mediated Innate Immune Responses
Interferon regulatory factor 3 (IRF3) is important for innate antiviral responses; accordingly, many viruses target and inactivate IRF3. The ability of the Herpes simplex virus type 1 (HSV-1) immediat
NIAID Data Ecosystem80
2′- O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo
Prior studies have shown that 2′-O methyltransferase activity of flaviviruses, coronaviruses, and poxviruses promotes viral evasion of Ifit1, an interferon-stimulated innate immune effector protein. V
NIAID Data Ecosystem60
Viral Bcl-2 homologs and their effect on the intrinsic apoptotic pathway.
Viral Bcl-2 homologs and their effect on the intrinsic apoptotic pathway.
Figshare2023-12-13 更新20
Alignment of EV71 VP3 protein from subgenogroups and escape mutants.
Partial alignment of the VP3 protein sequences of EV71 strains from representative subgenogroups, escape mutants, and coxsackievirus A16. The four escape mutations are highlighted in the boxes. While
NIAID Data Ecosystem60
The crystal structure of the complement inhibitory domain of Borrelia hermsii FbpC.
The crystal structure of the complement inhibitory domain of Borrelia hermsii FbpC.
NIAID Data Ecosystem40
