Patient characteristics by sickle cell disease genotype.

*Unless otherwise indicated; † From Wilcoxon two-sample test for difference in medians or Pearson chi-square test of independence of groups. p values <0.002 remained significant after Bonferroni's adjustment for multiple comparisons; ‡Hemoglobin oxygen saturation; §Chronic transfusion therapy; ||Stage I or higher. SBP = systolic blood pressure; DBP = diastolic blood pressure; MAP = mean arterial pressure; WBC = white blood cell count; LDH = lactate dehydrogenase; AST = aspartate aminotransferase; ALT = alanine aminotransferase; ALP = alkaline phosphatase; ACR = urine albumin-to-creatinine ratio; eGFR = estimated glomerular filtration rate; CKD = chronic kidney disease; TRV = tricuspid regurgitant jet velocity; NT-proBNP = N-terminal prohormone of brain natriuretic peptide. Patient characteristics by sickle cell disease genotype.