Data underlying the publication: Histones and histone variant families in prokaryotes

The research objective was to make an overview of histones in prokaryotes and to categorize these histones. We have categorized these histones by predicting their monomeric and multimeric structures with AlphaFold2. Histones with similar predicted quaternary structures or with additional domains were categorized as one group. We provide functional insight into these histones from these predicted structures and by generating HMM profiles to find strongly conserved residues. The dataset contains the predicted structures shown in the article, the HMM profiles of all histone categories, and the list of prokaryotic histones.

本研究旨在全面梳理原核生物组蛋白并完成分类。本研究通过AlphaFold2预测原核生物组蛋白的单体与多聚体结构，并据此完成分类：将具有相似预测四级结构或携带额外结构域的组蛋白归为同一类群。本研究基于上述预测结构，并通过构建隐马尔可夫模型（Hidden Markov Model, HMM）特征谱以鉴定高度保守的氨基酸残基，为这类组蛋白提供了功能层面的解析视角。本数据集包含本文中展示的预测结构、所有组蛋白类别的HMM特征谱，以及原核生物组蛋白列表。