Triphenyl Phosphate (CAS No. 115-86-6): 5-Day Rat Gavage Toxicogenomic Study

Triphenyl phosphate (TPHP) is an organophosphate flame retardant currently on the market and used as a replacement for phased-out polybrominated diphenyl ethers. Toxicity information on this class of chemicals is inadequate. Herein, the NTP use short-term, in vivo transcriptomic studies to inform potential points of departure for TPHP. The National Toxicity Program (NTP) conducted a transcriptomic study on TPHP, in male Harlan Sprague Dawley rats. TPHP was dissolved in corn oil. Exposure was once daily for 4 days by oral gavage. TPHP (>99%) was tested at six doses (0, 55, 110, 220, 441, and 881 mg/kg body weight). On Day 5, animals were sacrificed, standard toxicological measures assessed, and the liver taken for gene expression studies using Affymetrix microarrays.