Crystal Structure of compound 1-mediated ternary complex of KRAS G12R GCP with pVHL:ElonginC:ElonginB
收藏Protein Data Bank Japan2025-11-26 更新2026-04-19 收录
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Crystal Structure of compound 1-mediated ternary complex of KRAS G12R GCP with pVHL:ElonginC:ElonginB Descriptor: (2S,4R)-1-[(2R)-2-[3-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, CITRATE ANION, Elongin-B, ... Authors: Wijaya, A.J, Karolak, N.K, Ciulli, A. Deposit date: 2025-06-13 Release date: 2025-11-12 Last modified: 2025-11-26 Method: X-RAY DIFFRACTION (2.83 Å) Cite: Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-Loaded KRAS(On) Alleles. J.Am.Chem.Soc., 147, 2025
创建时间：
2025-06-13
