Correlation between the different members of the mTOR pathway with overexpression/mutation of PIK3CA and activation of AKT (pAKT) or mTOR (pmTOR) in patients with OC.
Deletion of Uhrf1 resulted in stage 1-specific defects during iNKT cell development. To investigate the molecular mechanism, we sorted WT and Uhrf1-KO stage 1 iNKT cells and performed RNA-seq. By comp
The therapy-induced PML/RARA catabolism elicits the loss of APL-initiating cell self-renewal through PML NB reformation and P53 activation. These results explain the curative activity of the RA/arseni