Breast Cancer Family Registry Early-onset Breast Cancer GWAS

In order to enhance our understanding of the genetic etiology of breast cancer, this study analyzed 1,265,548 Hapmap3 single-nucleotide polymorphisms (SNP) among a discovery set of 3,523 EOBC incident cases and 2,702 age-matched population control women, all of whom were age 50 or younger at enrollment. Subjects were recruited from the eight sites, some of which oversampled cases with a personal or family history of breast cancer.]]> As described in http://cebp.aacrjournals.org/content/27/9/1057. Sample size of 4914 before qc (3876 cases and 1038 controls). Platform of Illumina HumanExome, phenotype of early-onset breast cancer.As described in https://link.springer.com/article/10.1007/s10549-017-4287-4. Sample size of 2954 after QC. Platform of Illumina HumanExome, phenotype of all-cause mortality after early-onset breast cancer.Eligible cases were non-Hispanic White women diagnosed with invasive breast cancer when 51 years or younger and not known to carry pathogenic mutations in BRCA1 (GeneID:672) or BRCA2 (GeneID:675). Eligible controls were non-Hispanic White women ages 20 to 51 years without a history of breast cancer.]]>