The potential causal association between systemic lupus erythematosus and endocrine and metabolic disorders in the East Asian population: A bidirectional two-sample Mendelian randomization study

<strong>Supplementary Table 1：</strong>Details of 23 SNPs used as IVs for MR analysis of SLE on GD. <strong>Supplementary Table 2：</strong>Details of 25 SNPs used as IVs for MR analysis of SLE on T2DM. <strong>Supplementary Table 3：</strong>Details of 27 SNPs used as IVs for MR analysis of SLE on OP. <strong>Supplementary Table 4：</strong>Details of 7 SNPs used as IVs for MR analysis of GD on SLE. <strong>Supplementary Table 5：</strong>Details of 74 SNPs used as IVs for MR analysis of T2DM on SLE. <strong>Supplementary Table 6：</strong>Details of 35 SNPs used as IVs for MR analysis of OP on SLE. <strong>Supplementary Table 7：</strong>Results of MR analysis for the causal effect of SLE on GD. <strong>Supplementary Table 8：</strong>Results of MR analysis for the causal effect of SLE on T2DM. <strong>Supplementary Table 9：</strong>Results of MR analysis for the causal effect of SLE on OP. <strong>Supplementary Table 10：</strong>Results of MR analysis for the causal effect of GD on SLE. <strong>Supplementary Table 11：</strong>Results of MR analysis for the causal effect of T2DM on SLE. <strong>Supplementary Table 12：</strong>Results of MR analysis for causal effect of OP on SLE. <strong>Supplementary Figure 1: </strong>Scatter plots of causal effect estimates for SLE on GD (A), GD on SLE (B), SLE on T2DM (C), T2DM on SLE (D), SLE on OP (E), OP on SLE (F). <strong>Supplementary Figure 2: </strong>(A) Leave-one-out plot of the estimates from genetically predicted SLE on GD; (B) forest plot of the estimates from genetically predicted SLE on GD; (C) Leave-one-out plot of the estimates from genetically predicted GD on SLE; (B) forest plot of the estimates from genetically predicted GD on SLE. <strong>Supplementary Figure 3: </strong>(A) Leave-one-out plot of the estimates from genetically predicted SLE on T2DM; (B) forest plot of the estimates from genetically predicted SLE on T2DM; (C) Leave-one-out plot of the estimates from genetically predicted T2DM on SLE; (D) forest plot of the estimates from genetically predicted T2DM on SLE. <strong>Supplementary Figure 4:</strong> (A) Leave-one-out plot of the estimates from genetically predicted SLE on OP; (B) forest plot of the estimates from genetically predicted SLE on OP; (C) Leave-one-out plot of the estimates from genetically predicted OP on SLE; (D) forest plot of the estimates from genetically predicted OP on SLE. <strong>Supplementary Figure 5: </strong>Funnel plots of causal effect estimates for SLE on GD (A), GD on SLE (B), SLE on T2DM (C), T2DM on SLE (D), SLE on OP (E), OP on SLE (F).