Clinical isolates used in this study.

STSS, streptococcal toxic shock-like syndrome; mut, mutation; SLO, streptolysin O; aa, amino acid; Ala, alanine; Arg, arginine; Asn, asparagine; Asp, aspartic acid; Cys, cysteine; Gln, glutamine; Glu, glutamic acid; Gly, glysine; His, histidine; Ile, Isoleusine; Leu, leucine; Lys, lysine; Met, methionine; Phe, phenylalanine; Pro, proline; Ser, serine; Thr, threonine; Trp, tryptophan; Tyr, Tyrosine; Val, valine; WT, wild type.
+ in csrS, csrR,and rgg, the same sequence as the wild typed gene of SF370. + in SLO, enhanced production. – in SLO, the same amount as the wild strain of SF370. Accession No. deposited in DDBJ.
*: Each gene of these isolates was presented in previous publications [2],[5].