The early effects of radiotherapy on gene expression in RM9 and MC38 tumor tissues.. The early effects of radiotherapy on gene expression in RM9 and MC38 tumor tissues.

To investigate irradiation-induced gene expression profile changes in the tumor microenvironment with a focus on DNA sensing pathways and CXCL/CXCR2 axis at early time points (3h, 12h, 24h) after irradiation. We then performed gene expression profiling analysis using data obtained from 4 tumor tissue from different mice at each time points and the unirradiated control group in both RM9 and MC38 tumor models. Overall design: Comparative gene expression profiling analysis of mRNA-seq data for unirradiated group and irradiated groups at 3h, 12h, 24h after irradiation.