Dexamethasone disturbs myogenesis via interaction between retinoic acid and FGF-ERK signals

Despite the common application in pregnancy at clinical practice, it remains ambiguous whether dexamethasone (Dex) exposure can affect embryonic somitogenesis and myogenesis. We showed the interaction between retinoic acid and FGF/ERK signals, which are involved in Dexamethasone-induced abnormal myogenesis during embryonic development. The findings will be contributable to the prevention and treatment of congenital skeletal muscle diseases induced by Dex application during pregnancy.