Estrogen metabolism

Estrogens are metabolized via hydroxylation by cytochrome P450 enzymes such as CYP1A1 and CYP3A4 and via conjugation by estrogen sulfotransferases (sulfation) and UDP-glucuronyltransferases (glucuronidation). In addition, estradiol is dehydrogenated by 17β-Hydroxysteroid dehydrogenase into the much less potent estrogen estrone. These reactions occur primarily in the liver, but also in other tissues. Description source: [https://en.wikipedia.org/wiki/Estrogen#Metabolism Wikipedia]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP697 CPTAC Assay Portal]

雌激素通过细胞色素P450酶（如CYP1A1和CYP3A4）进行羟基化代谢，以及通过雌激素硫酸转移酶（硫酸化）和UDP-葡萄糖醛酸转移酶（葡萄糖醛酸化）进行结合代谢。此外，雌二醇在17β-羟基类固醇脱氢酶的作用下转化为效力较低的雌激素雌酮。这些反应主要发生在肝脏，但也发生在其他组织中。描述来源：[https://en.wikipedia.org/wiki/Estrogen#Metabolism Wikipedia]。该途径上的蛋白质有通过[https://assays.cancer.gov/available_assays?wp_id=WP697 CPTAC检测门户]提供的针对性检测方法。