Adipoq regulates the MEK/ERK signaling pathway and does not affect the effect of thread-embedding therapy

Adipoq has important clinical application value, and its will play a role in acupuncture thread embedding needs to be confirmed. We knocked out the Adipoq gene, cut off 100bp of the first exon of the gene, and attempted to verify the effect of thread embedding during the labor process of experimental SD rats. Our model was successful, and heterozygous protein expression was obtained. The related signaling pathway protein MEK2 showed differences, and the downstream protein ERK of the pathway changed under external stimulation. Although there was no inflammation or abnormal biochemical indicators, it did not confirm that Adipoq plays a role in the labor process. At the same time, acupuncture thread embedding has a good analgesic effect during labor. These findings provide a theoretical basis for labor and clinical labor pain.