Alterations in the expression of long noncoding RNAs and mRNAs in extracellular vesicles derived from the murine heart post ischemia-reperfusion injury

Extracellular vesicles (EVs) play important roles in cardiovascular diseases by delivering multiple RNA molecular, such as lncRNAs and mRNA. However, the features and functional mechanisms of the lncRNAs and mRNA in cardiac EVs during ischemia-reperfusion (IR) remains poorly understood. Therefore, we performed RNA sequencing to profile the expression feature of lncRNAs and mRNAs and predict their potential functions. Cardiac extracellular vesicles (EVs) was isolated from C57BL/6J mice (10 weeks old, 26±1 g) in the sham and IR groups.