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Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses

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NIAID Data Ecosystem2026-05-02 收录
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scRNA-seq analysis of patient-derived xenografts (PDX) in immunocompromised mice transfected by an intratumorally injected lipid nanoparticle carrying the reporter mRNA encoding for aVHH revealed that an optimized lipid nanoparticle, LNP-IT, transfected malignant cell types of HNSCC tumors and upregulated RNA and protein metabolic pathways.

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2025-03-14
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