Age-dependent changes in transcription factor FOXO targeting in Drosophila melanogaster
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
FOXO transcription factors control numerous pathways involving metabolism, stress response, and longevity. Although direct targets of FOXO have been reported in various long-lived mutants and under stress conditions, no studies have investigated how normal aging impacts the cellular activity of FOXO. In this study, we compared genome wide dFOXO-bound sites in young and aged wild-type flies kept under normal feeding conditions to evaluate the dynamics of FOXO gene targeting during aging. Our results provide a new insight into FOXO chromatin targeting under a normal aging model and highlight the diverse regulatory mechanisms for FOXO transcriptional activity that are currently less understood.
提供机构：
Iowa State University
创建时间：
2022-02-20
