RNA-sequencing of Imiquimod-induced rat skin treated with or without epidural lidocaine injection

We use back skin of WT SD rats, or imiquimod(IMQ)-induced psoraisis-like rat model treated with or without epidural injection of 1% lidocaine. We isolate total RNA for RNA-sequencing. We manipulate imiquimod(IMQ) on rat back skin for consecutive 6 days. Epidural injection of 1% lidocaine are conducted from day 3 of IMQ induction for continuous 4 days. Rat back skin are collected on day 7 after sacrificing rats.