Overview of features across wtf driver genes.

Column 1 denotes the wtf driver gene, and columns 2–8 describe specific features of each gene and their encoded proteins. Column 2 notes if the gene has been shown to drive in fission yeast or been shown to encode for functional Wtf poison and antidote proteins in S. cerevisiae. Column 3 notes the number of exons in the gene, and column 4 notes the size of the Wtfantidote protein in amino acids. If the antidote sequence had a predicted coiled-coil domain, column 5 notes the size and location in the antidote protein as described in [15]. Column 6 notes the numbers of PY motifs (L/PPXY [25];) in exon 1. While some Wtfantidote proteins also have an additional PY motif in exon 2, we did not include that information here since those motifs are shared by the corresponding poison proteins as well. Column 7 notes the number of predicted transmembrane domains predicted by TMHMM2.0 [73,81]. Column 8 notes the length of the exon 3 coding sequence repeats (if present) in amino acids. Column 9 notes the length of the exon 4/6 coding sequence repeats (if present) in amino acids. NA (not applicable) here indicates that the repeats were not present in the Wtf protein. Column 10 mentions the reference(s) where these genes/encoded proteins were characterized. (XLSX)