Regulatory neutrophil transcriptional profiling

We report that pharmacologically-induced autoantigen-specific T-regulatory type 1 (TR1) cells and TR1 cell-induced B-regulatory (Breg) cells recruit neutrophils into the liver and program their transcriptome to generate regulatory neutrophils Overall design: We defined the transcriptional profile of neutrophils from liver and blood of pMHC-NP-treated and untreated NOD.c3c4 mice to define the transcriptional make-up defining the disease-regulatory nature of the liver neutrophils that arise in treated mice. We also studied the transcriptional changes in these liver regulatory neutrophils upon pMHC-NP therapy in the presence/absence of cytokine-blocking antibodies.