Genomic Characteristics of MPNs in IR-Exposed Patients

The study "Genomic Characteristics of Myeloproliferative Neoplasms in Patients Exposed to Ionizing Radiation following the Chernobyl Nuclear Accident" was designed as case-control study. We studied genomic characteristics of chronic Philadelphia chromosome-negative myeloproliferative neoplasm (MPNs) in Ukrainian patients who were previously exposed to Ionizing Radiation (IR) due to Chernobyl accident in comparison to unexposed MPN patients and controls (previously exposed to IR due to Chernobyl accident and unexposed people who were not diagnosed with any oncological condition at the moment of DNA sampling).]]> In the study, we enrolled 58 MPN patients diagnosed in different clinics of Ukraine between 2009 and 2016 and referred to the National Research Center for Radiation Medicine of Ukraine (Kyiv, Ukraine). The group of patients included 25 MPN patients exposed to IR during the Chernobyl nuclear accident in Ukraine and 33 IR-unexposed MPN patients with average age 52 years (range: 19 - 79). The cleanup workers and permanent residents in the radionuclide contaminated territories were included in the group of IR-exposed MPN patients. The controls included 96 female patients with average age 64 years (range: 49 - 79) who previously experienced IR (dose range: 8 - 650 mSv), but were not diagnosed with oncological conditions at the moment of DNA sampling; and 89 IR-unexposed Ukrainians: 34 males and 55 females with average age 45 years (range: 19 - 77) who were not diagnosed with oncological conditions or other severe diseases and considered as healthy at the moment of DNA sampling. The patients and controls provided written informed consent in accordance with the Declaration of Helsinki. The study was approved by the local National Research Center for Radiation Medicine (Kyiv, Ukraine) and Dana-Farber/Harvard Cancer Center (Boston, USA) ethics committees. World Health Organization (WHO) 2016 MPN diagnostic criteria were used to classify the types of MPN.]]>