Validation of small molecule activators and identification of altered signaling pathways underlying the age-related decline in proliferative capacity in human dermal progenitors

Intrinsic dysfunction of hair follicle dermal progenitors underlies phenotypic changes observed in aged dermis in rodents. The authors confirm similar age-related decline in function is present in adult human DPCs. RNA-Seq is utilized to identify further explanations for this functional decline in aged hDPCs. Overall design: Dermal progenitor cells were isolated from adult human dermis from aged (>40yo) and young donors to allow for comparison between transcriptomes that may lead to targeted therapeutic intervention for age-related dermal degeneration