Additional file 2 of Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes

Additional file 2: Table S1. Subject characteristics in relation to outcome at 36 months. Table S2. Subject characteristics table by subject. Table S3. Associations between ASD diagnosis, global CpG methylation, and the proportion of nRBCs. Table S4. ASD DMRs identified in discovery males with annotation and covariate association. Table S5. ASD DMRs identified in discovery females with annotation and covariate association. Table S6. ASD DMRs identified in males are maintained with adjustment for nRBC proportion. Table S7. ASD DMR methylation is associated with diagnosis after adjustment for all cord blood cell types. Table S8. ASD DMRs adjusting for sex identified in all discovery subjects with annotation and covariate association. Table S9. ASD DMRs identified in replication males with annotation and covariate association. Table S10. ASD DMRs identified in replication females with annotation and covariate association. Table S11. ASD DMRs adjusting for sex identified in all replication subjects with annotation and covariate association. Table S12. ASD DMRs replicate by region overlap with an independent computational method. Table S13. DMR methylation assayed by WGBS correlates with DMR methylation assayed by bisulfite pyrosequencing. Table S14. ASD DMRs replicate by region overlap with an independent sample set. Table S15. ASD DMRs replicated by region overlap with an independent sample set. Table S16. ASD DMRs replicated by differential methylation in an independent sample set. Table S17. ASD DMRs associated with autism severity among ASD subjects in multiple sample sets. Table S18. Replicated DMR and DMB genes with annotation. Table S19. ASD DMRs replicate by gene overlap with conservative mapping. Table S20. ASD DMBs identified in discovery males with annotation. Table S21. ASD DMBs identified in discovery females with annotation. Table S22. ASD DMBs identified in replication males with annotation. Table S23. ASD DMBs identified in replication females with annotation. Table S24. ASD DMB genes replicate in independent sample sets and overlap with DMR genes.

附加文件 2：表 S1. 在 36 个月时与结果相关的受试者特征。表 S2. 按受试者划分的受试者特征表。表 S3. 自闭症谱系障碍（ASD）诊断、全局 CpG 甲基化与 nRBCs 比例之间的关联。表 S4. 在发现男性中确定的 ASD DMR，附有注释和协变量关联。表 S5. 在发现女性中确定的 ASD DMR，附有注释和协变量关联。表 S6. 考虑 nRBC 比例调整后，在男性中维持的 ASD DMR。表 S7. 调整所有脐带血细胞类型后，ASD DMR 甲基化与诊断相关。表 S8. 考虑性别调整后，在所有发现受试者中确定的 ASD DMR，附有注释和协变量关联。表 S9. 在复制男性中确定的 ASD DMR，附有注释和协变量关联。表 S10. 在复制女性中确定的 ASD DMR，附有注释和协变量关联。表 S11. 考虑性别调整后，在所有复制受试者中确定的 ASD DMR，附有注释和协变量关联。表 S12. 通过区域重叠与独立计算方法复制的 ASD DMR。表 S13. 由 WGBS 测定的 DMR 甲基化与由亚硫酸氢盐测序法测定的 DMR 甲基化相关。表 S14. 通过区域重叠与独立样本集复制的 ASD DMR。表 S15. 通过区域重叠与独立样本集复制的 ASD DMR。表 S16. 通过独立样本集中的差异甲基化复制的 ASD DMR。表 S17. 在多个样本集中，与自闭症严重程度相关的 ASD DMR。表 S18. 附有注释的复制 DMR 和 DMB 基因。表 S19. 通过保守映射与基因重叠复制的 ASD DMR。表 S20. 在发现男性中确定的 ASD DMB，附有注释。表 S21. 在发现女性中确定的 ASD DMB，附有注释。表 S22. 在复制男性中确定的 ASD DMB，附有注释。表 S23. 在复制女性中确定的 ASD DMB，附有注释。表 S24. 在独立样本集中复制的 ASD DMB 基因与 DMR 基因重叠。