Genomic Signatures Reveal DNA Damage Response Deficiency in Brain Metastases of Colorectal Cancer

We performed RNA-Seq on primary colorectal cancer (CRC) tissues and brain metastatic tissues from two CRC patients. Differential expression analysis was conducted to find genes associated with brain metastasis. mRNA profiles of primary tissues and metastatic tissues were generated by deep sequencing using Illumina HiSeq platform. *** Raw sequencing data for all the samples will be available at the European Genome-phenome Archive (http://www.ebi.ac.uk/ega/).