Heinze1998_GnRH_LH

This a model from the article:
A mathematical model of luteinizing hormone release from ovine pituitary cells
in perifusion.

Heinze K, Keener RW, Midgley AR Jr. Am J Physiol
1998 Dec;275(6 Pt 1):E1061-71 9843750
,
Abstract:

We model the effect of gonadotropin-releasing hormone (GnRH) on the production
of luteinizing hormone (LH) by the ovine pituitary. GnRH, released by the
hypothalamus, stimulates the secretion of LH from the pituitary. If stimulus
pulses are regular, LH response will follow a similar pattern. However, during
application of GnRH at high frequencies or concentrations or with continuous
application, the pituitary delivers a decreased release of LH (termed
desensitization). The proposed mathematical model consists of a system of
nonlinear differential equations and incorporates two possible mechanisms to
account for this observed behavior: desensitized receptor and limited, available
LH. Desensitization was provoked experimentally in vitro by using ovine
pituitary cells in a perifusion system. The model was fit to resulting
experimental data by using maximum-likelihood estimation. Consideration of
smaller models revealed that the desensitized receptor is significant. Limited,
available LH was significant in three of four chambers. Throughout, the proposed
model was in excellent agreement with experimental data.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Heinze K, Keener RW, Midgley AR Jr. (1998) - version02

The original CellML model was created by:
Lloyd, Catherine, May

[e-mail]
The University of Auckland
The Bioengineering Institute
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