FUS and Tactile Neuromodulation in NHP VPL - Electrophysiology
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# Raw Macaque Electrophysiology Dataset ## Overview This dataset contains intracranial electrophysiology recordings from macaque VPL thalamus, acquired with a NeuroNexus V1x32-Edge (Vector Array) single-shank probe (32 sites, 100 µm pitch, 177 µm² iridium sites) on a Blackrock Cerebus system, during two conditions: - Focused ultrasound (FUS) neuromodulation, with sonication targeted at either: - VPL thalamus (co-located with the recording array), or - insular cortex (recording remains in VPL) - Tactile stimulation of the hand contralateral to the recording hemisphere (right-hemisphere VPL array → left-hand stimulation, unless a session notes otherwise) FUS target (VPL vs insular cortex) and tactile stimulation side are recorded in each run’s `events.tsv` `stim_site` column—treat that as the authoritative per-trial record. The data support the following publication: Zheng, N., Yang, P.F., Phipps, M.A. et al. Transcranial focused ultrasound modulates spiking, LFP, and BOLD activity in the primate thalamus. *Nat Commun* (2026). https://doi.org/10.1038/s41467-026-75826-8 ## Subjects Species: *Macaca fascicularis* and *Macaca mulatta* Subject identifiers have been anonymized. Additional subject information is provided in `participants.tsv`. ## Experimental design Extracellular electrophysiology was recorded from: VPL Focused ultrasound was targeted to: VPL or insular cortex The experiment included the following conditions: - Focused ultrasound stimulation - Tactile stimulation Event timing and stimulation parameters are provided in the corresponding `events.tsv` files. ## Electrophysiology acquisition Recording system: Blackrock Microsystems Recording hardware: CerePlex Direct with CerePlex M headstage Electrode/probe: NeuroNexus V1x32-Edge Number of channels: 32 Sampling frequency: 30 kHz (spikes), 1 kHz (LFP) Recording hemisphere: Right Recording location: VPL ## Data format Raw Blackrock files were read with NPMK (`openNSx`, `openNEV`) in MATLAB and written to NWB using MatNWB. File types may include: - `.nwb`: raw electrophysiology recording and metadata - `.tsv`: participant, channel, electrode, and event tables - `.json`: metadata describing corresponding files ## Data included sub-01: - Spikes dataset: FUS stimulation in VPL (`ses-ieeg01`) - LFP dataset: FUS stimulation in VPL (`ses-ieeg02`) - Tactile stimulation (left hand) (`ses-ieeg03`) sub-02: - Spikes dataset: FUS stimulation in VPL (`ses-ieeg01`) - LFP dataset: FUS stimulation in VPL (`ses-ieeg02`) - Spikes dataset: FUS stimulation in insular cortex (`ses-ieeg03`) - Tactile stimulation (left hand) (`ses-ieeg04`) ## Funding This work was supported by NIH grants: - NINDS RF1 NS126144 - NIBIB 1U18EB02935 ## Contact Li Min Chen Vanderbilt University Institute of Imaging Science, Vanderbilt University limin.chen@vanderbilt.edu Li Min Chen Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center limin.chen@vumc.org ## License CC0
