Intermolecular C–H Quaternary Alkylation of Aniline Derivatives Induced by Visible-Light Photoredox Catalysis

The
intermolecular direct C–H alkylation of aniline derivatives
with α-bromo ketones to build a quaternary carbon center was
reported with a visible-light catalysis procedure. The reaction covers
a variety of functional groups with good to excellent yields. A regioselectivity
favoring the ortho position for the amine group was
observed and investigated with Fukui indices and spectral methods.