Genomic Profile and Clinicopathological Analyses of Wild-Type Gastrointestinal Stromal Tumors

The driver genes of wild-type gastrointestinal stromal tumors (WT-GISTs), particularly quadruple WT-GIST (qWT-GIST), remain unclear. In this study, we collected 119 WT-GISTs from two cohorts and analyzed their clinicopathological and genomic features, particularly for qWT-GISTs. Next-generation sequencing (NGS) revealed several fusion genes and gene mutations, such as ARID1B, SETD2, and PLCG2, in qWT-GISTs. Further integrated KEGG pathway analysis revealed significantly enriched signaling pathways in qWT-GISTs, including the HIF-1.