Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb405
收藏Protein Data Bank Japan2024-01-24 更新2026-03-21 收录
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Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb405 Descriptor: 1-[(3,4-dichlorophenyl)methyl]-5-[2-(dimethylamino)ethyl]pyrrolo[3,2-c]pyridin-4-one, ATP-dependent 6-phosphofructokinase, CITRIC ACID, ... Authors: McNae, I.W, Dornan, J, Walkinshaw, M.D. Deposit date: 2019-02-26 Release date: 2020-03-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice. Nat Commun, 12, 2021
创建时间：
2019-02-26
