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STAT3/POSTN/GSTP1/JNK Axis Orchestrates Ferroptosis in Nucleus Pulposus Cells:A Potential Therapeutic Target for Intervertebral Disc Degeneration

Name: STAT3/POSTN/GSTP1/JNK Axis Orchestrates Ferroptosis in Nucleus Pulposus Cells:A Potential Therapeutic Target for Intervertebral Disc Degeneration
Creator: Lanzhou University Second Hospital
Published: 2026-06-14T20:48:34+08:00

integrated proteome resources2026-06-17 收录

椎间盘退变机制

铁死亡靶点治疗

数据链接：

https://www.iprox.cn/page/project.html?id=IPX0017769000 数据链接链接失效反馈

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资源简介：

STAT3/POSTN/GSTP1/JNK Axis Orchestrates Ferroptosis in Nucleus Pulposus Cells:A Potential Therapeutic Target for Intervertebral Disc Degeneration

应用场景：

提供机构：

Lanzhou University Second Hospital

创建时间：

2026-06-14

椎间盘退变机制

细胞生物力学

Nucleus pulposus cells were stretched using a FX-5000T Flexcell tension plus system (Flexcell International Corp., USA) with 18% elongation (0.2 Hz) for 24 h Overall design: To compare the effects of

NIAID Data Ecosystem90

GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc. GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc

骨髓代谢

椎间盘退变机制

Glucose is critical to the development, homeostasis, and survival of nucleus pulposus cells. GLUT1 is a major glucose transporter, a NP phenotypic cell marker, and highly expressed in nucleus pulposus

NIAID Data Ecosystem40

HO1 activates autophagy to protect intervertebral disc degeneration. HO1 activates autophagy to protect intervertebral disc degeneration

椎间盘退变机制

自噬保护机制

Intervertebral disc degeneration (IDD) is majorly resulted from disordered extracellular matrix (ECM) metabolism, including decreased anabolism and increased catabolism activities in the nucleus pulpo

NIAID Data Ecosystem40

Bushenhuoxue formula on Wnt/β-catenin signaling

椎间盘退变机制

中医干预

椎间盘退行性变（IDD）是腰痛的主要原因。本研究旨在探讨IL-1对IDD的影响及其与Wnt/β-连环蛋白信号传导的关系，并初步阐明中国传统配方布氏菌素配方（BSHXF）的影响。将30只C57BL/6小鼠随机分为正常对照组、椎间盘变性模型组、β-连环蛋白基因激活组、BSHXF+β-连环蛋白基因激活组和BSHXF+椎间盘变性模型组。8周后，进行影像学和组织病理学分析。观察椎间盘的病理变化，检测相关蛋白

Figshare2022-06-28 更新60

Reactive Oxygen Species promote Pyroptosis of Nucleus Pulposus Cells in Modic changes with disc herniation based on smart-RNA sequencing

椎间盘退变机制

焦亡与氧化应激

We performed Smart-seq 2 and analyzed the differential expression of genes and pathways of Modic change to comparator group. Additionally, we detect the role of reactive oxygen species on pyroptosis o

NIAID Data Ecosystem40

STAT3/POSTN/GSTP1/JNK Axis Orchestrates Ferroptosis in Nucleus Pulposus Cells:A Potential Therapeutic Target for Intervertebral Disc Degeneration

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