Little is known of the role of cytotoxic CD4+ T-cells (CTLs) in the control of human viral replication. Here, we investigate CD4+ T-cell responses to three immunodominant SARS-CoV-2 epitopes identifie

NIAID Data Ecosystem40

DataSheet_1_Depletion of Gut Microbiota Impairs Gut Barrier Function and Antiviral Immune Defense in the Liver.pdf

肠道-肝脏免疫轴

病毒感染免疫反应

Commensal gut microbiota protects the immune defense of extra-intestinal organs. Gut microbiota depletion by antibiotics can impair host antiviral immune responses and alter hepatitis B virus (HBV) in

NIAID Data Ecosystem30

Immune cells

免疫细胞动态

病毒感染免疫反应

We characterized human and mouse immune cells in SARS-CoV-2 infected and uninfected MISTRG6-hACE2mice by flow cytometry to evaluate the cells that drive immunopathology and viral clearance.We reported

NIAID Data Ecosystem90

T-bet+ Memory B-Cells Link to Local Cross Reactive IgG Upon Human Rhinovirus Infection

病毒特异性B细胞免疫

病毒感染免疫反应

Human rhinoviruses cause the common cold, and exacerbate chronic respiratory diseases. Although infection elicits neutralizing antibodies, these do not persist or cross protect across multiple rhinovi

NIAID Data Ecosystem30

Blood and lymph node response to respiratory syncytial virus infection in mice

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