Molecular mechanism of SNHG11 in human osteosarcoma cells

Osteosarcoma ( OS ) is a malignant bone tumor of mesenchymal origin, which is common in children and adolescents.  LncRNA SNHG11 plays an important regulatory role in a variety of cancers and plays a key role in the migration, invasion, proliferation of a variety of cancer cells. At present, there is no report on the function and regulatory mechanism of lncRNA SNHG11 in osteosarcoma.We found Overexpression of SNHG11 inhibited the proliferation of in human osteosarcoma U2OS cells and promoted apoptosis.Overexpression of SNHG11 in U2OS cells resulted in significant differential expression of 344 genes, including 82 up-regulated genes and 262 down regulated genes.The upregulated differentially expressed genes were not enriched in relevant biological processes on GO-P, among which HMGCS2 and IL24 deserve attention.Downregulated genes are enriched in GO-P for cell adhesion and migration, among which KRT17, CXCL14, TRIB2, COL5A1, CCL24, SOX2, and COL6A3 are worth paying attention to.  SNHG11 ..., , , # Molecular mechanism of SNHG11 in human osteosarcoma cells

[https://doi.org/10.5061/dryad.zgmsbccnm](https://doi.org/10.5061/dryad.zgmsbccnm)

## Description of the data and file structure

This project aims to detect the effect of overexpression of lncRNA SNHG11 on the proliferation and apoptosis of U2OS cells in human osteosarcoma cells. And high-throughput transcriptome sequencing was used to obtain RNA seq and ChIRP seq data affected by SNHG11. Combined with bioinformatics analysis methods, the interacting proteins, RNA, and DNA targets of SNHG11 in U2OS cells were analyzed.

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