ADME properties of Wi-A and Wi-N analyzed using QikProp.

Mol MW: Molecular weight of the molecule.SASA: Solvent accessible surface area.donorHB: number of hydrogen bonds that would be donated.accptHB: number of hydrogen bonds that would be accepted.QPlogS: predicted aqueous solubility.QPlogBB: predicted brain/blood partition coefficient.QPlogKp: predicted skin permeability.PercentHumanOralAbsorption: predicted human oral absorption on 0 to 100% scale.RuleOfFive: number of violations of Lipinski’s rule of five.