Novel and previously reported genomic loci that associate with serum B12 levels at P−9.

Association results for serum B12 in Icelandic and Danish study samples separately and combined. The effect allele is the allele associated with increased serum B12 levels. The effect is on a quantile normalized scale. Data were combined in fixed effect meta-analyses based on P-value and direction of effect adjusted for the number of individuals in each sample. Values of I2 are percentages.Chr., chromosome; EAF, effect allele frequency; HET, heterogeneity; SNV, single nucleotide variant.1The annotation is based on the RefSeq hg18.2The reference alleles based on Build 36 hg18 are shown in bold.3In the Icelandic data the strongest signal at the FUT6 locus is for rs708686 located 5′ to the FUT6 gene (see Table S3).4Danish data are given for the perfect proxy rs4267943 (1000 Genomes data: r2 = 1.0).