Data_Sheet_1_Case report: Treatment of cyclobenzaprine ingestion in two dogs with intravenous intralipid therapy.PDF

IntroductionThe objective of this case series is to describe the clinical signs and outcome of cyclobenzaprine ingestion in two dogs treated with intralipid emulsion (ILE) and supportive care.Case or series summaryTwo dogs presented for evaluation of cyclobenzaprine ingestion. A 4-year-old female spayed Rat Terrier (dog 1) presented within 4 h of ingestion of cyclobenzaprine (between 9.7 and 25.9 mg/kg). The dog experienced abnormal behavior, agitation, tremors, tachycardia, and hypertension. There were no significant clinicopathological abnormalities. The dog was treated with ILE, cyproheptadine, and activated charcoal. All clinical signs resolved after treatment. A 5-month-old female intact mixed-breed dog (dog 2) presented after ingestion of an unknown amount of cyclobenzaprine 2–3 h prior to presentation. The dog experienced dull mentation, tremors, loss of gag reflex, tachycardia, and hypertension. There were no significant clinicopathological abnormalities. Orogastric decontamination was performed via gastric lavage, and activated charcoal was given via orogastric tube, followed by ILE. All clinical signs resolved after therapeutic intervention.DiscussionThis is the first report documenting clinical signs of cyclobenzaprine toxicity in two dogs followed by successful treatment with gastric emptying, ILE, and supportive care.

引言本案例系列旨在描述两例使用肠外脂肪乳剂（ILE）和支持性护理治疗环苯扎平摄入的两只狗的临床体征和预后。案例或系列摘要两只狗因环苯扎平摄入接受评估。一只4岁的未绝育母性鼠猎犬（犬1）在摄入环苯扎平（剂量介于9.7至25.9毫克/千克）后4小时内就诊。该犬出现异常行为、烦躁不安、震颤、心动过速和高血压。未发现显著的临诊病理学异常。犬接受ILE、西替利嗪和活性炭治疗。治疗后所有临床体征均得到缓解。一只5个月的母性混合品种犬（犬2）在摄入不明量的环苯扎平后2-3小时就诊。该犬出现意识模糊、震颤、吞咽反射丧失、心动过速和高血压。未发现显著的临诊病理学异常。通过胃灌洗进行口腔胃部解毒，并通过口腔胃管给予活性炭，随后给予ILE。治疗后所有临床体征均得到缓解。讨论这是首次报告两例犬出现环苯扎平中毒的临床体征，并随后通过胃排空、ILE和支持性护理获得成功治疗的案例。