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Linker-free PROTACs efficiently induce the degradation of oncoproteins

Name: Linker-free PROTACs efficiently induce the degradation of oncoproteins
Creator: Southern University of Science and Technology
Published: 2025-01-20T16:34:28+08:00

integrated proteome resources2026-02-07 收录

PROTAC药物设计

靶向蛋白降解

数据链接：

https://www.iprox.cn/page/project.html?id=IPX0010911000 数据链接链接失效反馈

官方服务：

资源简介：

Linker-free PROTACs efficiently induce the degradation of oncoproteins

应用场景：

提供机构：

Southern University of Science and Technology

创建时间：

2025-01-20

靶向蛋白降解

肿瘤免疫治疗

Pharmacological degradation of receptor-interacting protein kinase 1 (RIPK1) offers a compelling therapeutic strategy to overcome its scaffolding role in tumor resistance and enhance the efficacy of i

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Discovery of Histone Deacetylase 8‑Specific Proteolysis-Targeting Chimeras with Anticancer Activity against Hematological Malignancies

靶向蛋白降解

肿瘤药物研发

Histone deacetylase 8 (HDAC8) has emerged as promising therapeutic target for several malignancies. In this study, we developed two series of cereblon (CRBN)-recruiting proteolysis-targeting chimeras

NIAID Data Ecosystem30

Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation

靶向蛋白降解

泛素-蛋白酶体系统

The intracellular levels of many proteins are regulated by ubiquitin-dependent proteolysis. One of the best-characterized enzymes that catalyzes the attachment of ubiquitin to proteins is a ubiquitin

PubMed Central2001-07-03 更新10

Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex

靶向蛋白降解

CDK8-cyclinC抗肿瘤靶点

The CDK8–cyclin C complex is an important anti-tumor target, but unlike CDK8, cyclin C remains undruggable. Modulators regulating cyclin C activity directly are still under development. Here, a series

Figshare2023-03-17 更新30

METTL5 blockade enhances anti-tumor immune response via inducing neoantigen generation

肿瘤免疫治疗

新抗原诱导

METTL5 blockade enhances anti-tumor immune response via inducing neoantigen generation

integrated proteome resources20