Expression data from brain parts (amygdala, hippocampus, prefrontal cortex, and cerebral cortex) from mice with or without chronic mild stress (CMS) treatments.

Accumulation of negative stressful life events caused major depressive disorder (MDD) a major public health problem related to disability around the world. For effective therapy and disease managements, a comprehensive genomic analysis to identify objective signatures is required to grasp pathophysiological changes and applicable markers. This data was from a chronic mild stress (CMS) induced MDD mouse model followed by Affmatrix cDNA expression array (GeneChip Mouse Genome 430 2.0 Array) analysis in amygdala, hippocampus, prefrontal cortex, and cerebral cortex. Mice with or without 4 weeks chromic unpredicted mild stress treatments were sacrificed and total RNAs were extracted from brain parts including amygdala, hippocampus, prefrontal cortex, and cerebral cortex of each independent mouse (n=3 for CMS treated and n=3 for control mice). GeneChip Mouse Genome 430 2.0 Array (Affymetrix, CA, USA) was used for whole genome expression profiling. The procedures are essentially followed according to the manufacturer’s manual.